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  5. Aquaporin 4 involves in neuropathic pain through spinal astrocytes activation

Aquaporin 4 involves in neuropathic pain through spinal astrocytes activation

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：starseekerwjy
【摘 要】
：
Aim: Spinal glias, including astrocytes and microglias, play an important role in neuropathic pain.Aquaporin 4 (AQP4), the predominant water channel exists in astrocytes, not only permeates water, but
【作 者】
：
Ning WU Ya-jie SUN Guan-yi LU Chong PANG Ying CHEN Jin LI 
【机 构】
：
Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
aquaporin 4 neuropathic pain astrocytes activation 
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Aim: Spinal glias, including astrocytes and microglias, play an important role in neuropathic pain.Aquaporin 4 (AQP4), the predominant water channel exists in astrocytes, not only permeates water, but also regulates extracellular K+ homeostasis and glutamate clearance.In the present study, the role of AQP4 in neuropathic pain was investigated.Methods: Effects of inhibiting AQP4 function or knockingout AQP4 gene on acute pain and chronic pain, including neuropathic pain, were observed.
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