重组人粒细胞集落刺激因子动员干细胞治疗终末期慢性阻塞性肺疾病的临床研究

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  目的 探讨重组人粒细胞集落刺激因子动员干细胞治疗终末期慢性阻塞性肺疾病的疗效。方法 回顾性分析福建医科大学附属第二医院血液科2013年1月至2013年10月份施行的重组人粒细胞集落刺激因子动员干细胞治疗2例终末期慢性阻塞性肺疾病患者的临床资料,分析治疗前后CAT评分、圣乔治评分、COPD综合评分等生活质量评分及FEV1、3FEV1/pred、三维肺部CT测量肺功能变化情况。结果 2例终末期慢性阻塞性肺疾病在应用重组人粒细胞集落刺激因子动员干细胞治疗2-3周期后CAT评分、圣乔治评分、COPD综合评分等生活质量评分及FEV1、FEV1/pred无明显改善,但三维CT测量肺功能指标有所改善。结论 重组人粒细胞集落刺激因子动员干细胞治疗终末期慢性阻塞性肺疾病是一种新的方法,值得临床推广。
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