Oncostatin M (OSM) protects against cardiac ischemia/reperfusion injury in diabetic mice by regulati

来源 :第17届中国南方国际心血管病学术会议 | 被引量 : 0次 | 上传用户:ding89629
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aim 0ncostatin M (0SM) exhibits many unique biological activities by activating 0β receptor.However, its role in myocardial I/R injury in diabetic mice remains unknown.The present study was to investigate the effects and mechanism of OSM on myocardial I/R injury in diabetic mice.
其他文献
Introduction Endothelium dysfunction plays a critical role in atherosclerosis.MicroRNAs are endogenous non-coding RNAs that suppress gene expression by binding to the 3 untranslated regions of target
会议
Objective It is well know that epigenetic plays an important role in controlling the regulation of gene expression during biological development.Troponin I is one of regulatory myofibril protein in he
会议
Bacground Cellular repressor of E1A-stimulated genes (CREG) is a lysosomal glycoprotein implicated in maintaining vascular homeostasis.However, the specific roles and the molecular mechanisms underlyi
会议
Background Cellular repressor of E1A-stimulated genes (CREG), a lysosomal glycoprotein implicated in cellular growth and differentiation, has been proposed be a new cardiovascular homeostasis regulato
会议
Background We hypothesized that mesenchymal stem cells (MSCs) overexpressing Cellular Repressor of E1A-stimulated Genes (CREG) showed improved survival and engraftment in the infarcted heart and promo
会议
Background After autologous saphenous veins grafted into arterial circulation via aortocoronary bypass surgery, the lumen of grafted veins is narrowed because of smooth muscle cells excessive hyperpla
会议
Background Bone mesenchymal stem cells (BMSCs) therapy has modest success in ischemic heart disease but has been limited by poor survival in diseased microenvironments.Cellular repressor of E1A-stimul
会议
目的 探讨丹参注射液(Danshen Injection,DSI)对急性心肌梗死后大鼠心室重构和心功能障碍的作用.方法 采用240±20 g SD大鼠,通过冠状动脉左前降支结扎复制心肌梗死模型,假手术组只开胸穿线不结扎.超声评价模型,将造模成功的大鼠随机分为模型组、缬沙坦组和丹参注射液组,假手术组及模型组生理盐水灌胃10 ml/kg/d,DSI组肌肉注射丹参注射液1.5 ml/kg/d,缬沙坦组灌
会议
Objective Macrophage inflammation plays an important role in the pathogenesis of atherosclerosis.In this study, we investigated the involvement of cellular repressor of E1A-stimulated genes (CREG) in
会议
Background Macrophage inflammation plays an important role in the pathogenesis of atherosclerosis.In this study, we investigated the involvement of cellular repressor of E1A-stimulated genes in tumor
会议