Suppression of Pu.1 Function Results in Expanded Myelopoiesis in Zebrafish

来源 :第三届全国斑马鱼研究大会 | 被引量 : 0次 | 上传用户：lsssyd

【摘要】

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　　Pu.1 plays critical roles in myeloid cell development and acts as a tumor suppressor in myeloid leukemia.Here we report a hypomorphic pu.1 zebrafish allele(

【作者】

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Jiping Sun Wangjun Liao Wei Liu Li Li Jiahao Chen Mei Wu Yiyue Zhang Anskar YH. Leung Wenqing Zhang Zilong Wen

【机构】

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DepartmentofOncology,NanfangHospital,SouthernMedicalUniversity,Guangzhou,China510515KeyLaboratoryofZ

【出处】

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第三届全国斑马鱼研究大会

【发表日期】

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2013年10期

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　　Pu.1 plays critical roles in myeloid cell development and acts as a tumor suppressor in myeloid leukemia.Here we report a hypomorphic pu.1 zebrafish allele(pu.1G242D)with reduced Pu.1 expression,in which the definitive myelopoiesis is altered as myeloid hyperplasia.We showed that immature myeloid cells of definitive origin begin to increase in the caudal hematopoietic tissue(CHT,a hematopoietic tissue equivalent to the mammalian fetal liver)of pu.1G242D larvae.

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Suppression of Pu.1 Function Results in Expanded Myelopoiesis in Zebrafish

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