"PEG dilemma" for PEGylated nanocarriers: accelerated blood clearance (ABC) phenomenon

• 作 者: ChunlingWang[1]YuqingSu[1]XiangLuo[1]TingZhang[1]XulingWang[1]LirongWang[1]YanzhiSong[1]XingrongLiu[1]ShaoningWang[2]YihuiDeng[1]
• 机 构: School of Pharmacy, Shenyang Pharmaceutical University, 103, Wenhua Road, Shenyang 110016, PR China
• 出 处: 2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
• 发表日期: 2015年期

　　Repeated intravenous injection of PEGylated nanocarriers , such as PEGylated emulsions (PE) ,PEGylated nanoparticles, PEGylated micelles, and PEGylated liposomes, alters the pharmacokinetics and biodistribution of the second administration, regarded as the "accelerated blood clearance (ABC) phenomenon.