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Nowadays, generic drugs hold high leading position in the clinical drugs in our country.Recently,many new regulation policies was brought out, the description of genetic drug is now defined as "having the same quality and therapeutic effect with Brand-name drug".Where is the future of generic drug R&D development? In this presentation, the questions of What/How to do and common deficiencies will be discussed in detail from the scientific point of view.Some thinking of generic drug R&D strategies will be put forward and wish to be paid more attention.