Mechanical Characterization of Cancer Cells in Epithelial-mesenchymal Transition Using an Electrodef

• 作 者: YaoTeng[1]MingshuPang[1]JianvongHuang[2]ChunyangXiong[3]
• 机 构: Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing
• 出 处: 2016年大连国际微纳流体和微流控芯片大会(2016 International Conference of Micro
• 发表日期: 2016年期

　　Cancer development and progression not only results in biological and functional abnormalities but also leads to changes in the mechanical and structural characteristics of cells.Numerous studies have shown a strong correlation between cell mechanical properties (stiffness or deformability) and cancer progression and malignancy.For example, the stiffness of metastatic cancer cells from body fluids of patients was reported 70% lower than the benign cells lining the body cavity.The mechanical characterization have been shown to be a promising and alternative way to diagnose cancer.