【摘 要】
：
目的:建立氯胺酮性膀胱炎大鼠尿液代谢指纹图谱信息。方法:运用气相色谱质谱联用(GC-MS)方法研究氯胺酮长期给药后引起膀胱炎大鼠尿液代谢组的变化,以全谱数据建立代谢指纹图谱。结果:对照组和氯胺酮组指纹色谱图结果为组内相似度较高,组间相似度较低。结论:本研究得到了大鼠尿液的代谢指纹图谱,为氯胺酮性膀胱炎毒性提供了鉴别依据,也为其诊断和治疗提供方向.
【机 构】
：
四川大学 华西基础医学与法医学院,四川 成都 610041;西南医科大学 附属医院药学部,四川 泸州646000
【出 处】
：
中国化学会第十九届全国有机分析及生物分析学术研讨会
论文部分内容阅读
目的:建立氯胺酮性膀胱炎大鼠尿液代谢指纹图谱信息。方法:运用气相色谱质谱联用(GC-MS)方法研究氯胺酮长期给药后引起膀胱炎大鼠尿液代谢组的变化,以全谱数据建立代谢指纹图谱。结果:对照组和氯胺酮组指纹色谱图结果为组内相似度较高,组间相似度较低。结论:本研究得到了大鼠尿液的代谢指纹图谱,为氯胺酮性膀胱炎毒性提供了鉴别依据,也为其诊断和治疗提供方向.
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