相变微滴乳剂联合HIFU肿瘤热疗的理论研究

来源 :2014年上海市研究生学术论坛:生物医疗仪器 | 被引量 : 0次 | 上传用户:gnayief
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  相变微滴被用于高强度聚焦超声(HIFU)热物理治疗可以大大缩短治疗时间,它的作用原理是相变微滴在HIFU焦点区域气化成为微泡,增加治疗区局部的热量。然而,关于这种新型的治疗方式的研究目前仅有少量实验方面的报道,为了得到参数全面的定量结果,挖掘其中的作用机理,本文建立了数值计算模型。模型中考虑了组织中存在相变微滴时,HIFU焦点处形成微泡后对声场的影响,将组织吸收超声能量转化的热能和微泡在超声作用下振动所产生的的粘性加热量加入到传热方程中,得到组织中存在不同浓度相变微滴时,HIFU治疗区域的温度分布和热变性区域的体积。模型计算得到的变性区域形状与文献中的实验结果类似。该模型改进后可以用于预测这种新型疗法的效果。
其他文献
Background: Selecting an appropriate number of surface electromyography(EMG)channels with the desired classification performance and determining the optimal placement of EMG electrodes would be necess
Multiple wavelet hypothesis and fibrillatory conduction are believed to be atrial fibrillations pathogenesis.Radio frequency ablation(RFA)technique,a therapy for atrial fibrillation(AF),applies radio
When using HIFU to ablate a tumor with large volume,numerous sonications are necessary to cover the whole treatment area in the traditional scanning method with single focus,because the focal size of
目的:本研究模拟了一款镍钛合金伞状脑保护装置在径向压握、自膨胀释放及血压作用下的情况,并对模型结构在各个接触载荷下的力学性能进行分析.方法:建立了伞状脑保护装置、压握工具以及目标血管的有限元模型.对圆柱状压握工具施加向内的径向位移沿R轴正方向施加大小为2.0mm的位移载荷,压握伞状脑保护装置至外径为2.0mm;将压握工具恢复到原始尺寸,建立血管/远端保护器接触关系;对伞状脑保护装置两端截面在轴向和
Screening and analysis of circulating tumor cells(CTCs)can potentially provide crucial information for clinical prevention,diagnosisand treatment of cancer metastasis.Herein we designed variousfunctio
Single Photon Emission Computed Tomography(SPECT)suffers limited detection efficiency and spatial resolution due to the need for collimators and un-direct conversion of scintillation detectors.Various
The 2D janus hybrid(gold NPs/graphene)superstructures were built via arapid,solventless sputtering method in 10 seconds.The size and morphology of gold NPs can be fine controlled by adjusting the sput
Auricular-prosthesis-based techniques have been developed for years to repair ears with defects.In order to obtain good aesthetics and functional effects of the auricular prosthesis,the following two
Intraoperative monitoring of cerebral blood flow(CBF)is of interest to neuroscience researchers,which offers the assessment of hemodynamic responses throughout the process of neurosurgery and provides
Laser speckle contrast imaging(LSCI)has shown it ssuccessfulness in full-field imaging of blood vessel and blood,with many advantages over the conventional laser Doppler flowmetry.Intraoperative monit