The Function of Enhancer Long non-coding RNA in the Human Genome

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户:anabaow1a1
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Background: More than 90 percent of the human genome is non-coding sequence.However,only a small number of these regions were well studied,such as transcriptional factor binding sites,enhancers,small noncoding RNA.The functions of most non-coding DNA are still unknown.In this paper,we focus on the long non-coding RNA produced from enhancer regions (enhancer lncRNA).
其他文献
Pseudo dinucleotide composition (PseDNC) and Z curve are two widely used feature extracted methods from DNA sequences,and both of them show excellent performance in the classification issues for nucle
Background: In 2003,we developed an ab initio program,ZCURVE1.0,to find genes in bacterial and archaeal genomes.In this work,we present the updated version (i.e.ZCURVE 3.0).Using 422 prokaryotic genom
Most natural protein sequences have resulted from millions or even billions of years of evolution.How they differ from random sequences is not fully understood.Previous computational and experimental
Tuberculosis is killing millions of lives every year and on the blacklist of the most appalling public health problems.Recent findings suggest that secretory protein of mycobacterium tuberculosis may
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against foreign DNA or RNA.The CRISPR-associated protein (Cas) system is a power
Background: Sorghum (Sorghum bicolor) is one of the most important cereal crops globally and a potential energy plant for biofuel production.In order to explore genetic gain for a range of important q
Copy number alteration (CNA) can directly affect the expressions of genes that are located in CNA regions,this phenomenon is called dosage effect.However,some studies indicate that a gain or loss in c
Although CRISPR/Cas9 system has been successfully applied to zebrafish studies,its efficiencies vary greatly for different gRNAs,even for those targeting on the same genes.As the workload and cost of
The transcription factor (TF) binding signals play important role in the control of gene expression.In this study,to elucidate the relationship between the transcription factor binding signals and gen
The solid tumor sample obtained from clinical practice is always a mixture of different tissue types.As a result,the high-throughput genomics/epigenomics measurements from tumor samples are mixed sign