槲皮素与槲皮素-铬(Ⅲ)的诱导白血病细胞K562凋亡的研究

来源 :中国化学会第十届全国天然有机化学学术会议 | 被引量 : 0次 | 上传用户：qinqincy

【摘要】

：

槲皮素(Quercetin)是黄酮醇的一种代表性化合物,其化学名为3,3,4,5,7-五羟基黄酮,具有降血压、抗肿瘤、预防糖尿病并发症等多种药理作用.槲皮素本身溶解性以及酸碱性的限制,极大地影响了槲皮素在生物体内的利用度,天然产物经过结构修饰,利用微量元素与天然活性成分之间的拮抗作用来降低毒性或者增强药效.本课题组利用槲皮素分子本身具有较高的超离域度、完整的大π键共轭体系、强配位能力的氧原子与三价

【作者】

：

梁安文沈鹏俞梅兰

【机构】

：

浙江理工大学生命科学学院,杭州,310018

【出处】

：

中国化学会第十届全国天然有机化学学术会议

【发表日期】

：

2014年11期

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