Computational Insight into Molecular Mechanism of Thioesterase-catalyzed Macrocyclization in Erythro

来源 :第十三届全国计算机化学学会会议 | 被引量 : 0次 | 上传用户：lxj364199013

【摘要】

：

　　Macrocyclic polyketides,biosynthesized by modular polyketide synthases(PKSs),have been developed into successful pharmaceuticals.Substantial efforts have be

【作者】

：

XiongpingChen;TingShi;Yi-LeiZhao;

【机构】

：

Shanghai Jiao Tong University,Shanghai,200240

【出处】

：

第十三届全国计算机化学学会会议

【发表日期】

：

2015年期

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　　Macrocyclic polyketides,biosynthesized by modular polyketide synthases(PKSs),have been developed into successful pharmaceuticals.Substantial efforts have been undertaken to elucidate the biochemistry of PKS,especially thioesterase(TE)-mediated macrocyclization; however,the mechanism is still poorly understood.

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Computational Insight into Molecular Mechanism of Thioesterase-catalyzed Macrocyclization in Erythro

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