Biocompatibility of Graphene Oxides with and without PVP coating

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户:hongmei61
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  Graphene oxide (GO) immunotoxicity is not clarified well up to date.Herein we reported the effects of GOs with and without polyvinylpyrrolidone (PVP) coating on human immune cells such as dendritic cells (DCs), T Lymphocytes and macrophages.Human immune cells such as dendritic cells (DCs), T Lymphocytes and macrophages were isolated from health donated bloods, PVP-coating GO (PVP-GO) exhibited lower immunogenicity compared with pure GO on the aspect of inducing differentiation and maturation of dendritic cells (DCs), the levels of secreted TNF-α and IL-1β had no obvious difference between two groups, yet the secretion of IL-6 remained in PVP-coating GO group.
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