Nanoparticle-assisted combination therapy against triple negative breast cancer by using miR-34a and

• 作 者: XiongweiDeng;ZhaoxiaYin;WangSheng;
• 机 构: College of Life Science and Bioengineering,Beijing University of Technology,No. 100 Pingleyuan,Beiji
• 出 处: 中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
• 发表日期: 2014年期

　　Metastatic relapse,development of drug resistance in cancer cells and adverse side effects of chemotherapeutic agents are the major obstacles for effective chemotherapy against triple-negative breast cancer.To address these problems,nanocarriers have been largely developed to encapsulate and deliver therapeutic agents and attracted increasing attention in miRNA delivery.In addition to nanocarriers designed to deliver a single therapeutic agent,there are growing interests in developing multi-agent co-delivery nanocarriers that can simultaneously incorporate and deliver multiple types of therapeutic payloads to disease sites in a targeted and controlled manner for combined therapy.