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  5. 2-Methoxyjuglone induces apoptosis in HepG2 human hepatocellular carcinoma calls and exhibits In viv

2-Methoxyjuglone induces apoptosis in HepG2 human hepatocellular carcinoma calls and exhibits In viv

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：vera_00
【摘 要】
：
In order to discover anticancer agents from natural sources, an ethanol-soluble extract of the root bark of Juglans cathayensis was investigated and showed cytotoxic effects against various human canc
【作 者】
：
Heng-yi YU Xiao-qiong ZHANG Xue LI Fan-bo ZENG Han-li RUAN 
【机 构】
：
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,Faculty of Pharmacy,Tong
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
Juglans cathayensis 2-methoxyjuglone apoptosis intrinsic pathway in vivo antitum 
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In order to discover anticancer agents from natural sources, an ethanol-soluble extract of the root bark of Juglans cathayensis was investigated and showed cytotoxic effects against various human cancer cell lines.A subsequent phytochemical study on the EtOAc-soluble fraction determined 2-methoxyjuglone (1) as one of the main active constituents.Compound 1 was shown to be cytotoxic against HepG2 cells.
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