Regulation of fibril formation of human Tau fragment by zinc

来源 :2013年第四届全国“跨学科蛋白质研究”学术讨论会 | 被引量 : 0次 | 上传用户：qq2285387

【摘要】

：

　　A hallmark of a group of neurodegenerative diseases such as Alzheimer disease is the formation of neurofibrillary tangles which are principally composed of

【作者】

：

王玉凝莫重瑛陈杰梁毅

【机构】

：

武汉大学生命科学学院,病毒学国家重点实验室,武汉430072

【出处】

：

2013年第四届全国“跨学科蛋白质研究”学术讨论会

【发表日期】

：

2013年10期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　A hallmark of a group of neurodegenerative diseases such as Alzheimer disease is the formation of neurofibrillary tangles which are principally composed of bundles of filaments formed by microtubule associated protein Tau.

其他文献

Biochemical dissection of bacterial virulence and macrophage innate immunity

　　Many bacterial pathogens use a type Ⅲ secretion system to inject virulent effector proteins into host cells.These effectors often use sophisticated biochem

会议

Structural and functional insights into the human BFLS associated protein PHF6

　　PHF6 gene was originally identified as the gene resulting in the X-linked mental retardation disorder, B(o)rjeson-Forssman-Lehmann syndrome (BFLS).Mutations

会议

Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract hos

　　Rab GTPases are frequent targets of vacuole-living bacterial pathogens for appropriate trafficking of the vacuole.Here we discover that bacterial effectors

会议

Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger recepto

　　Autophagy, the process of lysosome-dependent degradation of cytosolic components, is a mechanism by which cells selectively engulf invading pathogens to pro

会议

The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NS

　　The NSD (nuclear receptor SET domain-containing) family members, consisting ofNSD1, NSD2 (MMSET/ WHSC1), and NSD3 (WHSC1L1), are SET domain-containing methy

会议

Hfq bridged ternary complex is important for translation activation of rpoS by DsrA

　　The rpoS mRNA, which encodes the master regulator σs of general stress response, requires Hfq-facilitated base pairing with DsrA small RNA for efficient tr

会议

Structural basis of molecular mechanism of epigenetic regulation

　　Our laboratory use multi-dimensional NMR and crystallography to study structure, dynamics and function of proteins.We are interested in protein-protein, pro

会议

Aptamer-based methods for protein assay

　　Assay of proteins, especially those involved in signal transduction, electron transfer and some other bioprocesses and those working as biomarkers, is of gr

会议

基于多肽的蛋白质定量新技术

　　蛋白质疾病标记物的高灵敏检测对蛋白质定量方法提出了更高要求。近来我们致力于将多肽发展为一种新型蛋白质检测探针。多肽相对于抗体具有结构简单、易于人工合成、改造

会议

Zinc significantly changes the aggregation pathway and the structure of aggregates formed by human p

　　Transmissible spongiform encephalopathies (TSEs) are a group of infectious fatal neurodegenerative diseases, and prion protein is the key factor in TSEs.The

会议

Regulation of fibril formation of human Tau fragment by zinc

其他学术论文