The effect of receptor interacting protein 3 in cortex neuronal necroptosis induced by ischemia repe

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It was reported that there existed neuronal necroptosis following ischemia, but the mechanisms remained unclear.Our previous studies have shown RIP-3 acts in necroptosis following elevated hydrostatic pressure in retinal ganglion cell line 5.Now, we wonder if RIP3-phoRIP3-ROS pathway was involved in necroptosis of neurons induced by Oxygen Glucose Deorivation-Reperfusion (OGD-R).z-VAD was used to inhibit apoptosis of neurons.
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