论文部分内容阅读
Tetrahydroisoquinoline (THIQ) moiety is present in numerous structurally diverse natural products and pharmaceuticals.
Mechanochemical Oxidative Mannich Reaction of N-Boc Tetrahydroquinolines and Ketones: Evaluation of
【摘 要】
：
Tetrahydroisoquinoline (THIQ) moiety is present in numerous structurally diverse natural products and pharmaceuticals.
【机 构】
：
National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, C
【出 处】
：
2016年长三角药物化学研讨会
【发表日期】
：
2016年11期
其他文献
Microglia,the resident phagocytes of the CNS,plays an important role in the active immune defense and the progression of neuroinflammation.It is reported that inhibition of microglial activation contr
Discovery, Optimization, and Biological Evaluationin of Benzothiadiazine Derivatives (S-2-106) and (
会议
Alzheimers Disease (AD) is the most common form of dementia.The multi-target-directed ligands(MTDLs) designed for this fatal neurodegenerative disorder exhibit promising therapeutic potential.
One-pot facile synthesis of polysubstituted Pyridines via tandem reaction of Blaise reaction interme
会议
Synthesis and Evaluation of Novel Indol-Pyrazoline Hybrids as Potential Tubulin Polymerization Inhib
会议
Enantioselective Allylic Substitution of Morita-Baylis-Hillman Adducts Catalyzed by Chiral Bifunctio
会议
Synthesis of novel chromeno[3,4-b]pyrrol-4(3H)-ones through domino cyclization of 3-aminocoumarin wi
会议
本文介绍了一种芬太尼的改进工艺，着重在反应原料、反应条件、反应时间、工艺操作、工艺成本等方面做了相关改进。通过该工艺改进，反应条件简化、生产成本降低，比较适合工业化规模生产。