【摘 要】
：
目的 上皮性卵巢癌是死亡率最高的妇科恶性肿瘤.其浆乳癌发病率最高而透明细胞癌预后最差.近年发现,晚期浆乳癌病人年龄越大预后越差.目前miRNA已被誉为最有希望的靶性诊断,个体治疗与疾病预后的标志物.本研究拟探讨透明细胞癌与晚期老年浆乳癌在miRNA表达方面的异同,其与患者预后的关系,及病人存活率方面的标记物作用.方法 从病人手术切除的卵巢癌标本中提取总RNA(Ambion),测定RNA质量后(Ag
【机 构】
：
大连医科大学miRNA研究室 大连妇产医院
【出 处】
：
中华医学会第十四次全国妇科肿瘤学术会议
论文部分内容阅读
目的 上皮性卵巢癌是死亡率最高的妇科恶性肿瘤.其浆乳癌发病率最高而透明细胞癌预后最差.近年发现,晚期浆乳癌病人年龄越大预后越差.目前miRNA已被誉为最有希望的靶性诊断,个体治疗与疾病预后的标志物.本研究拟探讨透明细胞癌与晚期老年浆乳癌在miRNA表达方面的异同,其与患者预后的关系,及病人存活率方面的标记物作用.方法 从病人手术切除的卵巢癌标本中提取总RNA(Ambion),测定RNA质量后(Agilent),miRNA高通量基因芯片技术(由Harvard Clinic and Translational Science Center,USA操作)分别检测8例Ⅰ期透明细胞癌和9例Ⅲ期老年浆乳癌的miRNA表达差异.
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