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以移行性综合肌电(MMC)作指标,研究红霉素(EM)消化道副作用与平滑肌电活动的关系。结果发现,在狗消化间期,静脉注射EM50～400μg/kg,在3～7min内即诱发剂量依赖性早发MMCⅢ相。此早发Ⅲ相起于胃、十二指肠,向小肠尾端移行,其锋电发生率、Ⅲ相持续时间和移行速度等均与自发Ⅲ相类似。胃、十二指肠内分别注射EM500μg/kg,经24.5±7.5min和23.7±2.2min才诱发移行性Ⅲ相。双侧膈上迷走神经切除后,EM仍诱发早发Ⅲ相,但其移行速度减慢(p<0.01),阿托品能阻断EM诱发Ⅲ相的发生。EM在Ⅲ相诱发后的70～250min甚至更长时间内仍使MMC周期和Ⅲ相起始紊乱,甚至完全破坏MMG,代之以超速扩布锋电簇活动。EM不影响进食后狗的胃肠电活动。因此,EM消化道反应的发生可能与其被吸收进血液后通过内在胆碱能神经启动早发Ⅲ相及其后较长后效应有关。
The relationship between side effects of erythromycin (EM) digestive tract and the activity of smooth muscle was studied by using comprehensive electromyography (MMC) as an index. The results showed that during the digestive tract of dogs, intravenous injection of EM50 ~ 400μg / kg, within 3 ~ 7min induced a dose-dependent early MMC Ⅲ phase. The early onset of phase Ⅲ in the stomach, duodenum, to the tail of the small intestine migration, the incidence of electroporation, Ⅲ phase duration and migration velocity and spontaneous Ⅲ are similar. The stomach and duodenum were injected with EM500μg / kg respectively, and the transitional phase was induced by 24.5 ± 7.5min and 23.7 ± 2.2min. After bilateral phrenic vagotomy, EM still induced early phase Ⅲ phase, but the migration speed was slowed down (p <0.01). Atropine could block EM-induced phase Ⅲ. In the period of 70 ~ 250min or even more after the phase Ⅲ was induced by EM, the MMC cycle and phase Ⅲ still initiated disorder, even completely destroyed the MMG, and replaced by the ultrafast spreading frontal electric cluster activity. EM does not affect gastrointestinal electrical activity of dogs after eating. Therefore, the occurrence of EM digestive tract reactions may be related to its effect of initiating the early phase III and subsequent long-term effects by the intrinsic cholinergic nerve after it is absorbed into the bloodstream.