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Interleukin-17A (IL-17A) regulates various immune functions during microbial infections and autoimmunity.However, the role of IL-17A in the pathogenesis of West Nile virus (WNV) is not clear.Here we show that WNV induces IL-17A production in both mouse and human immune cells in vitro, and in plasma of WNV infected mice.Despite unaltered inflammatory cytokine expression and antibody production, IL-17A deficient mice (Ill7a-/-) are more susceptible to WNV infection and generate a higher viral burden in blood, liver, and brain after lethal WNV infection, when compared to wild-type (WT) mice.