The role of carnosine-histidine-histamine pathway in the CNS

• 作 者: YaoSHEN;Wei-WeiHU;Chun-LeiJIN;Shi-HongZHANG;ZhongCHEN;
• 机 构: Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hang
• 出 处: 中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
• 发表日期: 2007年期

　　Epilepsy is one of the most common neurological disorders and characterized by recurrent seizures,afflicting about 1% of the population.Previous studies show that histaminergic neuron system plays an important role in the pathogenesis of seizure disorders.The brain histamine seems to be involved in mechanisms regulating seizure susceptibility.However,histamine cant penetrate across blood-brain barrier (BBB) and it has been reported to be involved in brain inflammation.Camosine presents in muscle and brain of mammalian in high concentrations,carnosine serves as a reservoir for histidine,which is a precursor of histamine.It is proposed that there exist camosine-histidine-histamine pathway in the brain and plays certain important role in CNS.However,few reports have demonstrated the significant relations between brain carnosine and histamine.And there is only limited information about the effects of camosine on kindled seizures.