Thymoquinone attenuates monocrotaline-induced pulmonary arteryhypertension via inhibiting pulmonary

• 作 者: Ning Zhu Xuyong Zhao Yijia Xiang Wuming Hu Linchun Lv Shiyong Ye Jie Huang Chunlai Zeng
• 机 构: LishuiCentralHospital,Zhejiang,China
• 出 处: 2016年浙江省医学会心电生理与起搏学术年会
• 发表日期: 2016年6期
• 关键词: pulmonary arterial hypertension thymoquinone proliferation migration p38MAPK/NF-

　　Background:Pulmonary artery remodeling induced by excessproliferation,migration and apoptosis resistance of pulmonary arterial smooth muscle cells (PASMCs)is akey component in pulmonary artery hypertension (PAH).Thymoquinone (TQ) triggers cancer cells apoptosis through multiplemechanisms.In addition,TQ inhibits migration of human nonsmall-cell lung cancer cells and human glioblastoma cells.Objectives: In the current study,we investigated effects of TQ on MCT-induced PAH in rats and its underlying mechanisms.