【摘 要】
：
Cereal grain contamination by trichothecene mycotoxins is known to negatively impact human and animal health with adverse effects on food intake and growth being of particular concern.The head blight
【机 构】
：
College of Veterinary Medicine , Nanjing Agricultural University , Nanjing 210095, P.R.China
【出 处】
：
中国畜牧兽医学会家畜内科学会2014年学术研讨会
论文部分内容阅读
Cereal grain contamination by trichothecene mycotoxins is known to negatively impact human and animal health with adverse effects on food intake and growth being of particular concern.The head blight fungus Fusarium graminearum elaborates five closely related 8-ketotrichothecene congeners: (1) deoxynivalenol (DON), (2) 3-acetyldeoxynivalenol (3-ADON), (3) 15-acetyldeoxynivalenol (15-ADON), (4) fusarenon X (FX) ,and (5) nivalenol (NIV).While anorexia induction in mice exposed intraperitoneally to DON has been linked to plasma elevation of the satiety hormones cholecystokinin (CCK) and peptide YY3-36 (PYY3-36), the effects of oral gavage of DON or of other 8-keotrichothecenes on release of these gut peptides have not been established.The purpose of this study was to (1) compare the anorectic responses to the aforementioned 8-ketotrichothecenes following oral gavage at a common dose (2.5mg/kg bw) and (2) relate these effects to changes plasma CCK and PYY3-36 concentrations.Elevation of plasma CCK markedly corresponded to anorexia induction by DON and all other 8-ketotrichothecenes tested.Furthermore, the CCK1 receptor antagonist SR 27897 and the CCK2 receptor antagonist L-365,260 dose-dependently attenuated both CCK-and DON-induced anorexia, which was consistent with this gut satiety hormone being an important mediator of 8-ketotnchothecene-induced food refusal.In contrast to CCK, PYY3-36was moderately elevated by oral gavage with DON and NIV but not by 3-ADON, 15-ADON, or FX.Taken together, the results suggest that CCK plays a major role in anorexia induction following oral exposure to 8-ketotrichothecenes, whereas PYY3-36 might play a lesser, congener-dependent role in this response.
其他文献
The endometrium is easily contaminated with bacteria and the endometrial epithelial cells (EECs) play an important role in defence against invading pathogens which recognized pathogen-associated molec
Elevated plasma nonesterified fatty acids (NEFA) and hepatocytes damage are features of ketosis in dairy cows.Oxidative stress is involved in the pathogenesis of liver damage induced by NEFA.However,
A high plasma concentration of non-esterified fatty acids (NEFAs) is an important pathogenic factor that leads to ketosis and fatty liver in dairy cows.NEFAs may be associated with oxidative stress in
Escherichia coli is one of the important pathogens involved in the etiology of bovine mastiffs.A total of 70 E.colt isolates recovered from clinical and subclinical mastiffs samples were characterized
In this study, to exploit a safe and effective vaccine for the prevention against avian leukemia subgroup J, we have developed the investigation of the protective antibodies induced by prokaryotic exp
Eudragit L100 microcapsule was prepared to encapsulate zinc gluconate trihydrate (zinc gluconate) using emulsion solvent evaporation method and the optimum condition was investigated by response surfa
Locoweeds are toxic plants of the genera Astragalus and Oxytropis containing swainsonine.Swainsonine is the principal agent responsible for locoism in animals.Recently, the fungal endophytes are isola
Fluoride and sodium sulfite are two well known environmental contaminants, which pose a serious threat to male reproduction.The present study aims to determine the effects of exposure to fluoride and
The aim of this study was to carry out a survey for the presence of Giardia duodenalis infection in canine using ELISA and PCR and to identify risk factors for infection.Samples from 318 dogs faeces l
Porcine circovirus type 2 (PCV2) is recognized as a key infectious agent in post-weaning multisystemic wasting syndrome (PMWS), but not all pigs infected with PCV2 will develop PMWS.The aim of this wo