Molecular characteristics of the T cell receptor beta variable repertoire within peripheral lymphocy

• 作 者: Jiezuan Yang Ping Yi Haifeng Lu Ping Ye Linfeng Jin Hua Zhang Hongcui Cao Lanjuan Li
• 机 构: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospit
• 出 处: 中华医学会第四届全国病毒性肝炎慢性化、重症化基础与临床研究进展学术会议
• 发表日期: 2014年期

　　Background HBV-infected individuals are immune tolerant or have deleted HBV antigen-specific T cell clones, which are thought to underlie the pathogenesis in chronic asymptomatic HBV carriers (AsC).The importance of CD4 + and CD8 + T cells in protection against HBV is well known, and T cell receptor beta variable (TCRBV) reflects the composition and function of T cells.However, the molecular profiles of TCRBV in CD4 + , CD8 + T cell subsets and peripheral blood mononuclear cells (PBMCs) in AsC have not been well described.