【摘 要】
：
Objective: We aimed to elucidate the accuracy and limitations of 18F-fluoro-L-dihydroxyphenylalanine ([18F] DOPA positron emission tomography (PET) for Japanese patients with congenital hyperinsulinis
【机 构】
：
Department of Pediatrics, Kizawa Memorial Hospital Japan
【出 处】
：
BIT`s 2nd Annual World Congress of Endobolism-2012(2012第二届内分
论文部分内容阅读
Objective: We aimed to elucidate the accuracy and limitations of 18F-fluoro-L-dihydroxyphenylalanine ([18F] DOPA positron emission tomography (PET) for Japanese patients with congenital hyperinsulinism.Although [18F] DOPA PET is reported to be useful for precisely localising the focal form of congenital hyperinsulinism, previous reports are mostly from European and North American centres.Patients: Seventeen Japanese infants with congenital hyperinsulinism.Measurements: [18F] DOPA PET studies were performed, and the results were assessed by simple inspection or by a quantitative measurement termed the Pancreas Percentage, which expresses the uptake of the head, body, or tail of the pancreas as a percentage of the total maximum standardised uptake value of the whole pancreas.The results were compared with those of other studies, including genetic analysis and histology.Results: By simple inspection, when a single focal uptake was obtained, the localisation and histology were correct in all cases that underwent pancreatectomy.However, the overall results were consistent with the molecular diagnosis and histology in only 7/17 and 6/12 patients, respectively.The inaccuracy of PET studies by inspection was due to elevated background uptake that mimicked a diffuse or multifocal appearance.The accuracy improved substantially using the Pancreas Percentage;it was consistent with the molecular diagnosis and histology in 10/17 and 9/12 patients, respectively.Conclusions: In contrast to the results of previous reports, [18F] DOPA PET appears to be less efficient for diagnosing Japanese patients with congenital hyperinsulinism.However, the diagnostic accuracy is substantially improved when this technique is combined with the Pancreas Percentage.
其他文献
Cardiovascular system is regulated by divers array of hormones and neurotransmitters, which function both under physiological and pathological conditions of the organism.In the past decade it was show
Although fragility fractures are less common in men than in women, when they occur, these fractures are associated with higher morbidity and death during one year after fracture.Overall, one in five m
Glycosylation is but one of numerous ubiquitous post translational modification (PTM) of proteins and lipids.PTM plays a critical role in protein folding, stability and interactions.The transfer of in
Introduction: When we are faced an infertile patient it is necessary to perform a complete and accurate diagnosis before any kind of treatment: an accurate anamnesis, a complete physical examination (
Pancreastatin (PST) is one of the regulatory peptides derived from intracellular and/or extracellular processing of chromogranin A, the soluble acidic protein present in the secretory granules of the
The processes of membrane fusion and reshaping of subcellular organelles are disturbed in some types of endocrine disorders and mucolipidoses such as mucolipidosis Ⅳ (MLⅣ).This is a devastating neurol
The management of glycaemic control in people with type 2 diabetes is complex and requires people with diabetes to adjust and coordinate eating and physical activity around the demands of their daily
Basal insulin analogs are recognized as an effective method of achieving and maintaining glycemic control for patients with type 2 diabetes.However, due to the progressive nature of the disease, some
The impacts of high fat diet (HFD) induced maternal obesity that prone the offspring to metabolic diseases are well documented.However, the transgenerational effects of continuous HFD feeding of offsp
As the use of CT Scan and MRI continues raising an increasing number of adrenal nodules are being diagnosed.The work up of these nodules aims to detect functionality and risks factors for malignancy.T