【摘 要】
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Current pharmacological therapies used in clinical practice for individuals with cardiac, hepatic, renal or pulmonary fibrosis do not show desirable effects ; therefore, new targets of therapy are urg
【机 构】
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Department of Pharmacology,Third Military Medical University,Chongqing 400038,China
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Current pharmacological therapies used in clinical practice for individuals with cardiac, hepatic, renal or pulmonary fibrosis do not show desirable effects ; therefore, new targets of therapy are urgently required.Mitochondria play pivotal role in energy production, metabolism, serving as storage tanks of calcium ions and cell fate determination.Recent results of our experiments and other authors studies suggest that the electron transport chain dysfunction, electron leakage increasing, the accumulation of fragmented mitochondria, and the impairment in the mitophagy system contribute to pathogenesis of tissue fibrosis.Mitochondria targeting compounds exert promise in treating and attenuating the progress of these diseases, indicating potential strategies to target mitochondria in the treatment of tissue fibrosis.
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