【摘 要】
：
AIM: Sustained pressure overload results in adverse cardiac remodeling with myocardial hypertrophy and fibrosis.Some microRNAs are participated in this course.MicroRNA-378, which has been found cardia
【机 构】
：
Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital
【出 处】
：
中国病理生理学会心血管专业委员会第十五届学术大会暨国际心脏研究会中国分会第十二届学术大会
论文部分内容阅读
AIM: Sustained pressure overload results in adverse cardiac remodeling with myocardial hypertrophy and fibrosis.Some microRNAs are participated in this course.MicroRNA-378, which has been found cardiac enriched, was deeply repressed in the dysfunctional heart.
其他文献
AIM: In the study, we investigated how exogenous hydrogen sulfide (H2S) influenced streptozotocin (STZ)-induced diabetic myocardial injury through cardiac mitochondrial protection and nitric oxide syn
AIM: To investigate the protective effect of Astragalus polysaccharide (APS) on doxorubicin-induced cardiotoxicity in primary cultured neonatal rat ventricular myocytes (NRVMs), C57BL/6J mice models a
Cortistatin is a recently discovered neuropeptide that has emerged as a potential endogenous anti-inflammatory peptide.As a clinical syndrome, sepsis occurs when an infection becomes amplified, leadin
AIM: It has been widely recognized that excessive alcohol consumption results in myocardial injury, but the detailed mechanisms need further discussion.Therefore, this study was designed to investigat
AIM: Our previous research found that 16-week-old urea transporter B (UT-B) null mice had atrial-ventricular (A-V) conduction block, and made a hypothesis of myocardial mitochondrial dysfunction.
AIM: Proteasomal degradation is critical to maintaining cardiac function and is altered in various diseases.Angiotensin Ⅱ (Ang Ⅱ) acts as a growth factor to induce cardiac growth.Here we aimed to test
AIM: The co-administration of dexrazoxane (DEX) with each dose of doxorubicin (DOX) is an efficient strategy to relieve DOXinduced cardiotoxicity.However, the mechanisms underlying the cardioprotectiv
AIM: To study the anti-aging effects and mechanisms of polyamine on senescent hearts in rat.METHODS: Wistar rats were randomly divided into young group (3 months old), old group (20 months old) and sp
AIM: It is reported that qiliqiangxin capsule (QL) inhibits pressure overload-induced cardiac hypertrophy and autophagy in mice.However, the underlying molecular mechanism remains elusive.
目的:Rho相关激酶(ROCK)的活化在压力超负荷介导的左心室重构中发挥重要作用,然而其潜在的病理分子机制不是十分明确.在前期研究中,我们发现TGF-β1通过诱导ROCK活化和抑制内源性BMP-2水平,加重了心肌纤维化的程度;因此,我们试图通过外源性补充BMP-2分子观察是否可有效改善压力超负荷激活TGF-β1引起的心肌纤维化,并阐明内在的病理机制.