过表达BMP-2分子通过激活Smad6/Smurf1复合物拮抗TGF-β1/ROCK信号通路介导的心肌纤维化

来源 :中国病理生理学会心血管专业委员会第十五届学术大会暨国际心脏研究会中国分会第十二届学术大会 | 被引量 : 0次 | 上传用户：habits

【摘要】

：

目的:Rho相关激酶(ROCK)的活化在压力超负荷介导的左心室重构中发挥重要作用,然而其潜在的病理分子机制不是十分明确.在前期研究中,我们发现TGF-β1通过诱导ROCK活化和抑制内源性BMP-2水平,加重了心肌纤维化的程度;因此,我们试图通过外源性补充BMP-2分子观察是否可有效改善压力超负荷激活TGF-β1引起的心肌纤维化,并阐明内在的病理机制.

【作者】

：

王时俊杨春杰龚惠苑洁叶勇张国平贾剑国孙爱军葛均波邹云增

【机构】

：

复旦大学附属中山医院,上海市心血管病研究所,上海200032;复旦大学生物医学研究院,上海200032

【出处】

：

中国病理生理学会心血管专业委员会第十五届学术大会暨国际心脏研究会中国分会第十二届学术大会

【发表日期】

：

2014年3期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Urotensin Ⅱ protects cardiomyocytes from apoptosis induced by oxidative stress through cystathionine

Plasma urotensin Ⅱ (UⅡ) has been observed to be raised in the patients with acute myocardial infarction, and a lower UⅡ response is associated with severer injury of myocardium, suggesting a possible

会议

Exogenous hydrogen sulfide attenuates diabetic myocardial injury through cardiac mitochondrial prote

AIM: In the study, we investigated how exogenous hydrogen sulfide (H2S) influenced streptozotocin (STZ)-induced diabetic myocardial injury through cardiac mitochondrial protection and nitric oxide syn

会议

Astragalus polysaccharide suppresses doxorubicin-triggered cardiotoxicity:involvement of up-regulati

AIM: To investigate the protective effect of Astragalus polysaccharide (APS) on doxorubicin-induced cardiotoxicity in primary cultured neonatal rat ventricular myocytes (NRVMs), C57BL/6J mice models a

会议

Cortistatin protects against heart injury by inhibiting NLRP3-mediated inflammasome activation durin

Cortistatin is a recently discovered neuropeptide that has emerged as a potential endogenous anti-inflammatory peptide.As a clinical syndrome, sepsis occurs when an infection becomes amplified, leadin

会议

Relationship between myocardial apoptosis and endoplasmic reticulum stress in excessive alcohol cons

AIM: It has been widely recognized that excessive alcohol consumption results in myocardial injury, but the detailed mechanisms need further discussion.Therefore, this study was designed to investigat

会议

Quantitative proteomic study of myocardial mitochondria in urea transporter B knockout mice

AIM: Our previous research found that 16-week-old urea transporter B (UT-B) null mice had atrial-ventricular (A-V) conduction block, and made a hypothesis of myocardial mitochondrial dysfunction.

会议

Activation of the cardiac proteasome promotes afngiotension-induced hypertrophy by increasing ATRAP

AIM: Proteasomal degradation is critical to maintaining cardiac function and is altered in various diseases.Angiotensin Ⅱ (Ang Ⅱ) acts as a growth factor to induce cardiac growth.Here we aimed to test

会议

MicroRNAs participate in the cardioprotective activity of dexrazoxane against doxorubicin-induced ca

AIM: The co-administration of dexrazoxane (DEX) with each dose of doxorubicin (DOX) is an efficient strategy to relieve DOXinduced cardiotoxicity.However, the mechanisms underlying the cardioprotectiv

会议

Polyamine resists heart aging through inducing autophagy/inhibiting mitochondria oxidative damage in

AIM: To study the anti-aging effects and mechanisms of polyamine on senescent hearts in rat.METHODS: Wistar rats were randomly divided into young group (3 months old), old group (20 months old) and sp

会议

Qiliqiangxin capsuleinhibits pressure overload cardiac hypertrophy and autophagy via AT-1 receptor m

AIM: It is reported that qiliqiangxin capsule (QL) inhibits pressure overload-induced cardiac hypertrophy and autophagy in mice.However, the underlying molecular mechanism remains elusive.

会议

过表达BMP-2分子通过激活Smad6/Smurf1复合物拮抗TGF-β1/ROCK信号通路介导的心肌纤维化

其他学术论文