• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Enhanced solubility, stability and antitumor activity of the VESylated gemcitabine prodrug by co-ass

Enhanced solubility, stability and antitumor activity of the VESylated gemcitabine prodrug by co-ass

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：water198206
【摘 要】
：
A VESylated gemcitabine (VES-dFdC) prodrug,which can be self-assembled into nanoparticles in water,is described.VES-dFdC was designed to improve the efficacy of gemcitabine and to overcome its limitat
【作 者】
：
Jiahui Yu Haijing Meng Fang Du Jin Huang WeiLu Yu Luo 
【机 构】
：
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development,East China N
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
Co-assembly TPGS VES-dFdC nanocapsules micelle 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
　　A VESylated gemcitabine (VES-dFdC) prodrug,which can be self-assembled into nanoparticles in water,is described.VES-dFdC was designed to improve the efficacy of gemcitabine and to overcome its limitations such as short half-life,systemic toxicity,and drug resistance [1].However,VES-dFdC based nanoparticles were not sufficiently stable,and prone to precipitate in PBS or serum.
其他文献
Semiconducting polymer dots with phosphorescent Ir(Ⅲ)-complex for photodynamic cancer therapy
The past few years have seen great developments in the field of semiconducting polymer nanoparticles (SPNPs) in chemo/biosensing,bioimaging and therapy applications.The SPNPs have great potential due
会议
Ir(Ⅲ) complexphosphorescencephotodynamic therapypolymer dots
Stabilization of layered double hydroxide nanoparticles by bovine serum albumin pre-coating for drug
One of the major challenges for nanoparticles to be used as the drug/gene delivery phfform is their tendency to aggregate in electrolyte solution (physiological enviroment).The increased particle size
会议
layered double hydroxidebovine serum albumincolloidal stabilizationnanopartic
Integrated therapy on residual tumor after palliative operation using dual-phase drug releasing elec
Cancer is a leading cause of death worldwide and surgery remains the most effective treatment for the majority of cancer patients in the early stage of solid cancers.However,tumor recurrence sometimes
会议
residual tumorpH-sensitiveinflammationelectrospinning
Hyperbranched polyglycidol/phosphatidylcholine and phosphatidylethanolamine hybrid liposomes for the
Phospholipids are recognized as non-allergic,bio-friendly permeation enhancers due to their similarity to the constituents of biomembranes.Therefore,liposomes become versatile carriers for drug delive
会议
phospholipidhyperbranched polyglycidolliposomepH-sensitivitydrug delivery
Development of a novel elastic and macroporous chitosan hydrogel for wound healing application
Chitosan hydrogel wound dressings are biocompatible,biodegradable,antibacterial and hemostatic biomaterials.However,applications for conventional chitosan hydrogels are limited due to their poor solva
会议
chitosancitric acidhydrogelfreeze-thawwound healing
Environmental pH-sensitive polymeric nano-carriers for targeted tumor delivery
We have been exploiting inherent tumor properties in the delivery of anticancer therapeutic materials and aimed specifically at acidosis and vascular leakiness for the development of versatile environ
会议
cancer therapygene deliverypH-sensitivelocalized delivery
A new metastable form of glycolide obtained via large scale high pressure experiments
Glycolide is an important molecule,as a precursor to the biodegradable and biocompatible polymers poly(glycolic acid) (PGA) and poly(lactic-co-glycolic acid) (PLGA).These polymers are both important i
会议
high pressurepolymorphismX-ray diffractionraman spectroscopy
Folate conjugated PEG-chitosan/graphene oxide nanocomplexes as potential carriers for pH-triggered d
Graphene oxide (GO) has shown important potential in drug delivery systems owing to its unique physical and chemical properties.However,GO is soluble in water but aggregated in physiological environme
会议
graphene oxidechitosan-PEGfolate-conjugatedpH sensitivedrug delivery
Development of biodegradable electrospun nanofibers containing 17-AAG
Electrospinning has been widely to produce polymeric nanofibers due to simple method and feasibility of large scale production.Polymeric nanofibers have become attractive materials due to high surface
会议
PCL/PLGA nanofibers17-AAGelectrospinningsingle nozzledual nozzle
Cisplatin complexes stabilized poly(glutamic acid) for controlled delivery of doxorubicin
Doxorubicin hydrochloride (DOX·HCl),an anthracycline antibiotic,is used in the first line treatment for a wide range of cancers.In order to reduce the side effects of free DOX·HCl,many nanocarriers ha
会议
poly(L-glutamic acid)doxorubicincisplatindrug deliverynanoparticles