【摘 要】
：
Solid-phase extraction (SPE) has been widely used to purify and enrich analytes of interest from complex samples.Among various sorbents, the mixed-mode sorbent seems to be more promising than others s
【机 构】
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Key Laboratory of Analytical Chemistry for Biology and Medicine, College of Chemistry and Molecular
【出 处】
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第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
论文部分内容阅读
Solid-phase extraction (SPE) has been widely used to purify and enrich analytes of interest from complex samples.Among various sorbents, the mixed-mode sorbent seems to be more promising than others since it could combine multiple interaction mechanisms into one single sorbent and offer some unique selectivity.In this work, a silica based mixed-mode weak cation exchange (silica-WCX) was prepared for SPE via the reaction of Cu(Ⅰ)-catalyzed azide-alkyne cycloaddition.Firstly, the surface of silica was modified by 3-azidopropyltriethoxysilane.Then, the modified silica reacted with 5-hexynoic acid and l-dodecyne in the presence of copper (Ⅰ) catalyst sequently.The resultant silica-WCX was characterized by FT-IR and element analysis.After that, five primary aromatic amines (PAA) in water was enriched by this sorbent and analyzed by HPLC-UV.Fig 1 showed that silica-WCX could enrich the PAAs in water effectively.Under the optimized conditions, the limits of detection of the five PAAs varied from 0.08 to 0.28 μg/L (S/N=3) and the recoveries were between 70.0%-113.5%.The intra-day and inter-day precisions (RSD, n=5) were in the ranges of 2.8-7.8% and 2.6-6.1%, respectively.
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