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A partition coefficient is a parameter reflecting hydrophobicity of chemical regents and is commonly assessed as the characteristic factor which affects the bio-availability of the chemical compound in the pharmaceutical area.The parameter typically used is the partition coefficient of octanol versus water, which is expressed in common logarithms of concentration ratio (LogPow).However, since there are some technological consideration and requirement of experienced skills for the operation in the existing methods, it is to be desired that an automated methodology for determination of LogPow with high reliability and efficiency is developed.In this presentation, we demonstrate the applicability of the developed method for the automated determination of partition coefficient using the UHPLC auto-sampler with reliability and high throughput analysis.