MicroRNA-21 is involved in Osteosarcoma cell invasion and migration

• 作 者: LiuXiaoyun;YangShuhua;WuZiyan;
• 机 构: Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science an
• 出 处: 全国骨关节与风湿病暨第三届武汉国际骨科高峰论坛
• 发表日期: 2012年期

　　MicroRNAs are involved in different cancer-related processes.MicroRNA-21 (miR-21),as an oncomiR,is overexpressed in all kinds of tumors and the role of miR-21 in carcinogenesis is elucidated in many cancers gradually.However,the function of miR-21 in osteosarcoma is still unclear.In our study,we found that miR-21 was significantly overexpressed in osteosarcoma tissues.More importantly,we confirmed that knockdown of miR-21 greatly decreased cell invasion and migration of MG-63.Furthermore,we identified that RECK (reversion-inducing-cysteine-rich protein with kazal motifs),a tumor suppressor gene,was a direct target of miR-21.Finally,the expression of RECK protein negatively correlated with the expression of miR-21 in human osteosarcoma tissues,indicating the potential regulation of RECK by miR-21.Our results suggest that miR-21 expression has a key role in regulating cellular processes in osteosarcoma,likely through regulating RECK and may serve as a therapeutic target.