A New Rotavirus VP6-based Foreign Epitope Presenting Vector and Immunoreactivity of VP4/VP7 Epitope

• 作 者: YumeiTeng[1]BingxinZhao[1]XiaoxiaPan[2]YYuandingChen[1]
• 机 构: Institute of Medical Biology,Chinese Academy of Medical Sciences & Peking Union Medical College,Kunm
• 出 处: 第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会
• 发表日期: 2015年期

　　The VP6 is the group antigen protein of group A rotavirus(RVA),constituting about 39%of the viral structure proteins by weight.The high degree of identity in the primary amino acid sequences of VP6 proteins suggests VP6-based vaccines could potentially provide heterotypic protection.Although,some effort has been directed toward producing recombinant rotavirus VP6 vaccines,the native VP6 is still unsatisfactory as an optimal vaccine.