CTLA-4 polymorphisms and haplotype correlate with survival and aGVHD after allogeneic stem cell tran

• 作 者: X-YQin[1]YWang[1]G-XLi[1]Y-ZQin[1]F-RWang[1]L-PXu[1]HChen[1]WHan[1]J-ZWang[1]X-HZhang[1]Y-JChang[1]K-YLiu[1]X-JHuang[2]Z-FJiang[3]
• 机 构: Peking University People's Hospital,Peking University Institute of Hematology,Beijing,China
• 出 处: 第十五届全国实验血液学学术会议
• 发表日期: 2015年期

　　Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been established as an effective treatment for patients with hematological malignancies.Disease relapse remains a major cause of transplant failure.T cell homeostasis is critical to determine the potency of the GVT effect.Cytotoxic T lymphocyte antigen-4 (CTLA-4 or CD 152) is a T cell activation negative regulator.Recent studies have shown the association of the CTLA-4 polymorphisms with the outcome after HLA-identical sibling allogeneic HSCT.