Protein phosphatase 2A inhibitor LB1 acts via miR-181b-1 to enhance daunorubicin cytotoxicity in sec

• 作 者: HongyanTong[1]JieJin[2]ChaoHu[2]ChenMei[2]MengxiaYu[2]LiYe[2]
• 机 构: 浙江大学医学院附属第一医院城站分院血液科MDS中心
• 出 处: 第十五届全国实验血液学学术会议
• 发表日期: 2015年期

　　Background Myelodysplastic syndromes (MDS) are hematologic malignancies that lack effective treatments, especially in cases when they evolve into leukemia.Protein phosphatase 2A (PP2A) helps regulate the cell cycle and apoptosis in MDS, leading us to explore whether and how the small-molecule PP2A inhibitor LB 1 can potentiate the chemotherapeutic activity of daunorubicin on secondary acute myeloid leukemia (sAML) evolved from MDS.