【摘 要】
：
Radiofrequency electromagnetic fields(RF-EMFs)have been classified by the International Agency for Research on Cancer as possible carcinogens for humans;however,this conclusion is based on limited epi
【机 构】
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Bioelectromagnetics Laboratory,Zhejiang University School of Medicine,Hangzhou 310058
【出 处】
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中国生物化学与分子生物学会2016年全国学术会议
论文部分内容阅读
Radiofrequency electromagnetic fields(RF-EMFs)have been classified by the International Agency for Research on Cancer as possible carcinogens for humans;however,this conclusion is based on limited epidemiological findings and lacks solid support from experimental studies.In particular,there are no consistent data regarding the genotoxicity of RF-EMFs.To address this issue,we investigated the effects of 1800 MHz RF-EMF on genomic integrity in mouse embryonic fibroblasts(MEFs)sufficient(Atm+/+)or deficient(Atm-/-)in ataxia telangiectasia mutated(ATM),a chief guardian of genomic stability.In Atm+/+MEFs,1800 MHz RF-EMF at an average special absorption rate of 4.0 W/kg induced significant DNA singlestrand breaks(SSBs)at 1-h exposure,and activated the SSB repair mechanism,resulting in reduced DNA damage compared to the background level at 36-h exposure.In Atm-/- MEFs,the same RFEMF induced not only SSBs but also double-strand breaks at 12-h exposure,activated the two repair processes,and also reduced the DNA damage to less than the control level after prolonged exposure.The phenomenon of reduced DNA damage was also observed in cells treated with toxic substances at low doses,which has been identified as hormesis in toxicology.So,to the best of our knowledge,this is the first study to report a hormesis-like effect of RF-EMF.
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