【摘 要】
：
In recent years,a growing body of evidence has shown a close connection between the neuro-immune system,especially the cytokine expression and the pathophysiology of mood disorders.Recent studies have
【机 构】
：
School of Medicine,Yunnan University,2 Cuihu North Road,Kunming,Yunnan,P.R.China,650091.
【出 处】
：
第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
In recent years,a growing body of evidence has shown a close connection between the neuro-immune system,especially the cytokine expression and the pathophysiology of mood disorders.Recent studies have confirmed that cordycepin(3-deoxyadenosine,3-dA)regulates the expression levels of anti-inflammatory and pro-inflammatory cytokines in the peripheral nervous system.Here,we intraperitoneal injected the mice with two doses of cordycepin(5mg/kg,12.5mg/kg),then studied the effects of cordycepin in the central nervous system and its therapeutical target in regulating the cytokines levels in the prefrontal cortex(PFC)and hippocampus(HIP)via Western blot.We found that the expression levels of anti-inflammatory cytokines IL-4 and IL-10,as well as pro-inflammatory cytokines IL-1β and TNF-α were significantly regulated after the treatment of cordycepin.After 45-minute treatment with cordycepin,only 12.5mg/kg group showed a significant increase in IL-4 expression in the PFC.After 5-day treatment,cordycepin significantly up-regulated IL-4 and IL-10 levels in both PFC and HIP.Moreover,45-minute treatment with cordycepin did not cause significant changes in IL-1β and TNF-α expressions.However,after 5-day treatment,cordycepin significantly reduced IL-1β levels in PFC,as well as TNF-α levels in both PFC and HIP.In addition,IL-6 expression levels did not show any change after cordycepin treatment.This study provide novel evidence that cordycepin regulates cytokine expression in the central nervous system,which might offer new pharmacological mechanism(s)in the treatment of neuro-immune related diseases.
其他文献
It is well-established that neuroimmunity is involved in the pathophysiology and treatment of mood disorders.Dectin-1 is a β-glucan(including lentinan; LNT)receptor that regulates immune functions and
Astrogliosis is a hallmark of many neurological disorders,yet its regulatory molecular mechanisms remain elusive.Here we used genetically engineered animal models to change ErbB signaling in adult res
Temporal lobe epilepsy(TLE)is the most common type of epilepsy and is often medically refractory.Here we report pharmaco-genetical approaches that allow cell-type specific inhibition of neuronal excit
Tree shrew(Tupaia belangeri),more closely related to primates than rodents,has been regarded as a promising model to study on stress-related disorders.But the mechanism underlying the susceptibility t
Objective: To determine the over-generation of Aβ and NFT in brain induced by composited Aβ and elucidate the improvement and effective mechanism of Scutellaria barbata flavonoids(SBF)on memory impair
In Parkinsons disease(PD),dopaminergic neurons in the substantia nigra(SN)are selectively degenerated,while those in the neighboring ventral tegmental area(VTA)are spared.Characteristics of ATP-sensit
The RIO(right open reading frame)kinases(RIOKs)include RIOK1,RIOK2 and RIOK3.Each member is implicated in 40S ribosomal subunit synthesis.Emerging evidence has suggested an important role of RIOKs in
Lycium barbarum polysaccharide(LBP)is a traditional Chinese wolfberry major functional components.Recent there is emerging evidence show that it has neuro-protection and reproductive protection.This s
CD147 belongs to immunoglobulin superfamily and can stimulate the surrounding fibroblasts to secret matrix metalloproteinases(MMPs).Studies showed that when compared with their normal counterparts,CD4
G-protein-coupled estrogen receptor 1(GPER1)has been implicated in neuroprotection of selective estrogen receptor modulators(SERMs)against various insults in the brain.However,the cellular mechanisms