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Objective: Obesity is becoming a worldwide health problem that increases the risk of somatic and psychosocial complications.Glycosylation as one of the most important posttranslational modifications has been reported to associate with many diseases.Since plasma glycans were significantly associated with body mass index (BMI) in both Croatian and Chinese population, the present study aims to determine the association between Immunoglobulin gamma (IgG) N-glycome, which is closer to biological function, and BMI in a northern Chinese population.Method: A cross-sectional study was carried out in Beijing,China from January to April of 2012.Plasma IgG N-glycome was determined using ultra-performance liquid chromatography (UPLC) on Waters BEH Glycan chromatography column.LASSO was used to reduce dimensions of glycans.Multiple linear regression model was used to identify the association between BMI and the directly or derived measured glycans.Results: Multiple linear regression reveled that glycan peak (GP) 2, GP11, GP18 and GP21 had a positive correlation with BMI, while GP5, GP14, GP17 and GP24 had a negative correlation with BMI, after controlling for age and sex.The percentage of sialylation of fucosylated galactosylated structures with bisecting GlcNAc in total IgG glycans (B=-0.126, P =0.002), the percentage of disialylation of fucosylated digalactosylated structures in total IgG glycans (B=0.273, P =0.034) and the percentage of fucosylation of digalactosylated structures (B=-0.194, P =0.006) were found to be statistically significant after controlling for age and sex.Which means, BMI is associated with the decrease of sialylation and increase of fucosylation.Conclusion: The increase of core fucosylation and decrease of sialylation of IgG are associated with the increased BMI.The study might help to the deciphering pathogenies of chronic inflammation that involved in the development of obesity.