【摘 要】
：
Antimicrobial peptides play an important role in the development of novel antibiotics because of their broad-spectrum antimicrobial activities and specific
【机 构】
：
SchoolofLifeScience,LiaoningNormalUniversity,Dalian116081,China;LiaoningProvincialKeyLaboratoryofBio
论文部分内容阅读
Antimicrobial peptides play an important role in the development of novel antibiotics because of their broad-spectrum antimicrobial activities and specific antimicrobial mechanism.In this present study,chensinin-1,a natural antimicrobial peptide,was isolated,purified and structurally characterized from the skin secretions of Chinese brown frog,Rana chensinensis.Chensinin-1 contains 18 amino acid residues and its primary structure is SAVGRHGRRFGLRKHRKH-NH2.Chensinin-1 displays selective antimicrobial activity against Gram-positive bacteria,was inactive against the growth of Gram-negative bacteria,and had no hemolytic activity on human erythrocytes.
其他文献
Kringle domains are composed of about 90 amino acid residues.They are are found throughout the blood clotting and fibrinolytic proteins.In recent years,kringle
Kidney ischemia reperfusion(IR)injury is a major cause of delayed graft function and increases the risk of allograft rejection,affecting both short-and long
Heart failure syndromes have significant impact on mortality and economic costs.Despite extensive research conducted,new drug agents are still required for
The renin-angiotensin system plays key roles in the regulation of blood pressure and electrolyte,and body fluid dynamics.Recently,big angiotensin-25(Bang-25
In the past decade,bacterial resistance to most antibiotics has prompted interest in developing novel antimicrobials.Developing antimicrobials for Gram-negative
This study was designed to determine the effects of sample collection and storage conditions on the measurement of ghrelin in bovine plasma samples.Two RIA
Protein posttranslational modifications(PTMs)generally refer to the covalent addition of functional groups to the amino acid residues 错误! 未找到引用源.,in
As a well-known powerful mucosal adjuvant peptides,Escherichia coli heat-labile enterotoxin(LT),especially the non-toxic or low toxic mutants(LTm),is capabl
Sulfonopeptides represent an important class of biologically active peptides,and have witnessed considerable applications in medicinal chemistry and clinica
A significant recent advance in chemical biology has been the development of chemoselective peptide ligation methods for protein synthesis.[1] These methods