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A significant recent advance in chemical biology has been the development of chemoselective peptide ligation methods for protein synthesis.[1] These methods provide a powerful technology for protein structure-function studies.Many of the currently available ligation chemistries are characterized by a typical prior capture step employing special amino acid sidechain functional group.[2] Herein,a potentially general aldehyde capture peptide ligation method which do not reliant on sidechain functional group was developed.