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Background: Cultural context affects the meaning of suicide (e.g., Canetto, 2008; Colucci, 2006).The meaning of suicide is how suicide is conceptualized in terms of cultural normative values (i.e., secular and sacred)in a cultural community (Boldt, 1988).Suicide in Ghana is becoming a considerable public health problem (Hjelmeland et al, 2008; Knizek, Akotia, and Hjelmeland, 2011) and in order to intervene there is the need to understand the behaviour within the Ghanaian cultural context.There are no reliable statistics on suicide.The act is criminalized by the state and also socioculturally prohibited.Already, some studies have provided indications that the cultural context in Ghana affects the meaning of suicidal behaviour as an act for women to defy or submit to oppressive patriarchal expectations, and as an act for men to convey their critical need of honour preservation (e.g., Adinkrah, 2010; Sefa-Dede and Canetto, 1992).Methods: To further our understanding of the meaning of suicide and how suicide can be prevented in the Ghanaian cultural context, the attitudes of various groups of people (i.e., psychology students, health professionals, lay persons) toward suicide have been studied using qualitative method.Results: Religious and societal values were found as critical cultural forms that influence attitudes and the meanings of suicidal behaviour.For instance, the religious ideologies that life belongs to God and thus is precious; that religion has an adaptive function and thus a persons inability to cope during crisis constitutes a faith-failure, make suicide a religious transgression.Additionally, the ideology that suicide carries an indelible stigma that affects the social image of others (e.g., the family) makes the act a social hazard and injurious in the Ghanaian cultural context.Conclusion: Suicide is a moral issue in Ghana and any intervention program must be sensitive to the cultural context.