【摘 要】
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Competitive enzyme inhibitors are of interest mainly for medicinal applications.Structure of inhibitor,the extent of its interaction with the enzyme,and the way the enzyme responds to the inhibitor ar
【出 处】
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中国上海第七届国际新药发明科技年会
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Competitive enzyme inhibitors are of interest mainly for medicinal applications.Structure of inhibitor,the extent of its interaction with the enzyme,and the way the enzyme responds to the inhibitor are among the major factors determining the effectiveness of the medicine.Tyrosinase inhibitors have come to attention in recent decades for medical,nutritional,and cosmetic purposes.However,the side effect and the effectiveness of the introduced formulations which contain,at least,one of the tyrosinase inhibitors are matter of controversy.Considering the fact that tyrosinase is a tetrameric allosteric enzyme [1],we paid attention to the way it responds to the inhibitor.Therefore,during our recent works on tyrosinase [2-4],inhibition of both cresolase and catecholase activities of mushroom tyrosinase were studied in the presence of various linear,non-linear,and aromatic inhibitors (Following Figure).
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