Microwave and Flow Cell Assisted Synthesis of Bioactive Molecules

来源 :中国上海第七届国际新药发明科技年会 | 被引量 : 0次 | 上传用户:mikecxybb
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  Examples,from our group,will highlight the use of microwave based technology in enabling the rapid,efficient synthesis of libraries of molecules of relevance to the pharmaceutical sector.For example,we have employed molybdenum hexacarbonyl for the rapid reduction of nitroarenes to anilines with excellent chemoselectivity,high yields and short reaction times.The synthesis of important kinase inhibitor precursors ahd antitrypanosomal molecules using a combination of microwave and flow cell chemistries is described.
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