BN大鼠OVA肠道过敏模型的建立及发病机理

来源 :第五届东方检验医学学术会议 | 被引量 : 0次 | 上传用户：tangdeqian1102

【摘要】

：

目的：通过大鼠的背部注射卵清蛋白(OVA)的致敏方式,建立BN大鼠的过敏模型,探讨其发病机理.方法：将20只BN大鼠分为PBS对照组和实验组,利用伊红苏木精HE染色,用透射电镜观察大鼠肠道炎症,同时采用ELISA和PCA两种方法检测血清中OVA抗原及IgE、IgG.结果：肠绒毛病理变化发现OVA过敏实验组较对照组可见小肠黏膜水肿,肠微绒毛严重损伤,炎症细胞数目显著增多主要是以嗜酸性粒细胞肥大细胞为

【作者】

：

万倩

【机构】

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同济大学附属杨浦医院

【出处】

：

第五届东方检验医学学术会议

【发表日期】

：

2016年10期

【关键词】

：

过敏反应动物模型肠道肥大细胞卵清蛋白过敏

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BN大鼠OVA肠道过敏模型的建立及发病机理

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