Hepatitis B virus replicates through an RNA intermediate.The lack of proofreading capacity of the viral DNA polymerase,coupled with the high rate of HBV rep
Hepatitis C virus(HCV)is a positive-sense single-stranded RNA virus of the Flaviviridae family.HCV exists in an infected individual as quasi-species with an
The CRISPR/Cas9 system is a novel genome editing technology which has been successfully used to inhibit HBV replication.Here we described a novel gRNA-micro