Identification of naturally occurring HBc mutations that compensate the replication fitness of a lam

• 作 者: Yaoyue Kang Yongmei Zhang Jinyu Wang Yijun Zhang Yanli Qin Hongyan Liu Haoxiang Zhu Richeng Mao Ran Yan Haitao Guo Dawei Cai Jiming Zhang
• 机 构: Department of Infectious Diseases,Huashan Hospital,Shanghai Medical College,Fudan University,Shangha
• 出 处: 中华医学会2015年医学病毒学大会
• 发表日期: 2015年期

　　Hepatitis B virus replicates through an RNA intermediate.The lack of proofreading capacity of the viral DNA polymerase,coupled with the high rate of HBV replication,result in the potential for mutations to be generated within the entire genome.