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Par-4 (prostate apoptosis response-4) is a leucine zipper protein of about 38 kDa that plays an important role in apoptosis of many type of cells.The par-4 (PAWR) gene was initially isolated in a differential screen for genes that are up-regulated during apoptosis of prostate cancer cells.However, Par-4 is widely expressed in diverse normal tissues and cell types and conserved during evolution.The par-4 gene has been mapped to human chromosome 12q2 1.Functional studies in a variety of cancer and neuronal cells indicated that Par-4 expression was necessary to induce apoptosis, since blockade of Par-4 activity (by co-expression of a dominant negative regulator of par-4 or RNA interference) prevented apoptosis.