【摘 要】
：
Background,Motivation and Objective The nucleus to cytoplasm ratio(N:C) is a parameter commonly used during histopathological assessment of biopsied tissues.Cells exhibiting malignant characteristics
【机 构】
：
Ryerson University,Canada
论文部分内容阅读
Background,Motivation and Objective The nucleus to cytoplasm ratio(N:C) is a parameter commonly used during histopathological assessment of biopsied tissues.Cells exhibiting malignant characteristics have enlarged nuclei due to their increased DNA content and thus demonstrate a larger N:C ratio than non-malignant cells.The most common method of determining the N:C ratio involves using optical microscopy to examine a sample of biopsied tissue to assess the cross sectional area of both nucleus and cytoplasm;however the stereological interpretation of the N:C ratio may be inaccurate depending on the cellular cross section being assessed.High frequency ultrasound(US) and photoacoustics(PA) may be used to determine a more accurate N:C ratio,as the diameter of cells in suspension can be directly calculated without the need for inference using 2D cross sections.
其他文献
Background,Motivation and Objective We have recently performed a study where what we term the average phase derivative(APD) of the RF data was successfully used to assess carotid plaque vulnerability.
Background,Motivation and Objective Fiber architecture is of major interest in the cardiac function.Recently,Backscatter Tensor Imaging(BTI),a new imaging technique enabled the detection of fiber orga
Background,Motivation and Objective The feasibility of noninvasively measuring regional carotid artery stiffness by way of the stress-strain relationship was recently demonstrated in young normal adul
Background,Motivation and Objective Cardiac ablation is increasingly used to treat atrial fibrillation.Although it is effective,the nonuniform thickness of the left atrial wall and the variable thickn
Background,Motivation and Objective Rupture-prone vulnerable plaques are characterized by a core of necrotic debris and lipids,accumulation of inflammatory cells and a reduced content of fibrous tissu
Background,Motivation and Objective Surgery is the only curative treatment in patients with colorectal liver metastases(CLM),but only 10–20 ％of patients are eligible.High Intensity Focused Ultrasound
Background,Motivation and Objective Tumor microenvironments play an important role on drug penetration within solid tumor.Although anticancer drugs can extravasate into tissue via enhanced permeabilit
Background,Motivation and Objective Our ultimate goal is to use focused ultrasound within curative protocols in the mouse and in human medicine.Curing mice with ultrasound is challenging as highly abs
Background,Motivation and Objective Bisphosphonates(BP) like zoledronic acid(ZOL) have demonstrated clinical utility in the treatment of patients with bone metastases.However,ZOL exhibits antitumor ef
Background,Motivation and Objective There is an increasing interest in non-invasive kidney sparing therapy for renal cancer,since～1.6 ％of men and women will be diagnosed with kidney and renal pelvis