【摘 要】
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Background,Motivation and Objective Tumor microenvironments play an important role on drug penetration within solid tumor.Although anticancer drugs can extravasate into tissue via enhanced permeabilit
【机 构】
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Department of Biomedical Engineering and Environmental Sciences,National Tsing Hua University,Hsinch
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Background,Motivation and Objective Tumor microenvironments play an important role on drug penetration within solid tumor.Although anticancer drugs can extravasate into tissue via enhanced permeability and retention effect,the extravascular diffusion is still restricted by the higher interstitial fluid pressure.Recent studies have demonstrated that ultrasound sonication can vaporize perfluorocarbon droplets into the gaseous phase.The so-called acoustic droplet vaporization(ADV) can reportedly be used to liberate encapsulated anticancer drugs in droplets for tumor treatments.In this study,we investigated the improvement of drug penetration via disrupting tumor vasculature induced by ADV.
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